What are the common signs and symptoms of Acute Lymphoblastic Leukaemia (ALL) as described in the chapter?

Common signs and symptoms of Acute Lymphoblastic Leukaemia (ALL) include increased lethargy, persistent fever, recurrent infections, prolonged bleeding, easy bruising, pallor, enlarged lymph nodes, and pain in the abdomen, bones, and joints. CNS involvement can lead to headaches and vomiting.

Acute Lymphoblastic Leukaemia (ALL) presents with various signs and symptoms due to the replacement of normal bone marrow cells with immature blast cells. Patients often experience lethargy and malaise, along with persistent fevers of unknown origin. They are also prone to recurrent infections due to low white blood cell counts, prolonged bleeding from low platelet counts, and easy bruising. Other symptoms may include pallor, swollen lymph nodes, and pain, particularly in the abdomen, bones, and joints. In cases where the central nervous system is affected, symptoms can include headaches and vomiting.