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What are the three main processes that occur simultaneously during the inflammatory response following tissue injury?

The three main processes that occur simultaneously during the inflammatory response following tissue injury are mast cell degranulation, activation of plasma protein systems, and movement of phagocytic cells to the injury site.

Mast cell degranulation involves the release of granules containing serotonin and histamine, which contribute to the inflammatory signs and symptoms. The activation of four plasma protein systems—complement, clotting, kinin, and immunoglobulins—supports the inflammatory process by orchestrating responses, stopping bleeding, enhancing vascular permeability, and destroying bacteria. Lastly, the movement of phagocytic cells to the area allows for the phagocytosis of bacteria and the removal of debris, facilitating healing.

Key points

  • Mast cell degranulation releases serotonin and histamine.
  • Four plasma protein systems are activated: complement, clotting, kinin, and immunoglobulins.
  • Phagocytic cells move to the injury site to clear debris and pathogens.
Source:Fundamentals of Applied Pathophysiology: An Essential Guide for Nursing and Healthcare Students· Inflammation, immune response and healing· p. 93–99

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Fundamentals of Applied Pathophysiology: An Essential Guide for Nursing and Healthcare Students

Ian Peate

THIRD EDITION · John Wiley & Sons Ltd

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