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What are the common adverse effects associated with angiotensin receptor antagonists compared to ACE inhibitors?

Common adverse effects associated with angiotensin receptor antagonists include dizziness, headache, hypotension, and gastrointestinal disturbances. In contrast, ACE inhibitors can cause hypotension, dizziness, headache, hyperkalaemia, and a non-productive cough.

Angiotensin receptor antagonists generally do not induce cough or clinically significant hyperkalaemia, making them better tolerated than ACE inhibitors. While both classes can cause dizziness and hypotension, ACE inhibitors are also associated with hyperkalaemia and a persistent cough due to their mechanism of action involving bradykinin. Therefore, angiotensin receptor antagonists may be preferred for patients who experience cough as a side effect of ACE inhibitors.

Key points

  • Angiotensin receptor antagonists cause dizziness, headache, hypotension, and gastrointestinal disturbances.
  • ACE inhibitors can lead to hypotension, dizziness, headache, hyperkalaemia, and a non-productive cough.
  • Angiotensin receptor antagonists are better tolerated and less likely to cause cough or significant hyperkalaemia than ACE inhibitors.
Source:Fundamentals of Pharmacology: An Applied Approach for Nursing and Health· Antihypertensive drugs· p. 478–483
Cover of Fundamentals of Pharmacology: An Applied Approach for Nursing and Health

Fundamentals of Pharmacology: An Applied Approach for Nursing and Health

Alan Galbraith ... [et Al.].

Second Edition · Routledge

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