What are the common adverse effects associated with risperidone as an atypical antipsychotic?
Common adverse effects associated with risperidone include weight gain, orthostatic hypotension, and the risk of neuroleptic malignant syndrome (NMS). Although it has a lower incidence of parkinsonism and galactorrhoea compared to other antipsychotics, some extrapyramidal symptoms may still occur.
Risperidone, as an atypical antipsychotic, is known to cause several common adverse effects. These include weight gain due to its 5-HT antagonism and antihistaminic properties, orthostatic hypotension from its α2 antagonistic effects, and the potential for neuroleptic malignant syndrome (NMS). While it is less likely to cause parkinsonism and galactorrhoea compared to traditional antipsychotics, some extrapyramidal symptoms may still be present. Overall, risperidone is considered to have a more favorable side effect profile than many older antipsychotics.
Key points
- Weight gain is a common effect due to 5-HT antagonism.
- Orthostatic hypotension may occur, especially at the start of treatment.
- Neuroleptic malignant syndrome (NMS) is a serious but rare risk.
- Lower incidence of parkinsonism and galactorrhoea compared to traditional antipsychotics.
Fundamentals of Pharmacology: An Applied Approach for Nursing and Health
Alan Galbraith ... [et Al.].
Second Edition · Routledge