ComparisonAdvanced
How does the malate-aspartate shuttle differ from the glycerol 3-phosphate shuttle in terms of ATP yield?
The malate-aspartate shuttle yields approximately 2.5 ATP per NADH, while the glycerol 3-phosphate shuttle yields about 1.5 ATP per FADH2. Therefore, the malate-aspartate shuttle is more efficient in terms of ATP production compared to the glycerol 3-phosphate shuttle.
Key points
- Malate-aspartate shuttle produces ~2.5 ATP per NADH.
- Glycerol 3-phosphate shuttle produces ~1.5 ATP per FADH2.
- Malate-aspartate shuttle is more efficient for ATP yield.
- Both shuttles transfer reducing equivalents into mitochondria.
Source:Marks' Basic Medical Biochemistry: A Clinical Approach· Oxidative Phosphorylation and Mitochondrial Function· p. 497–503
Marks' Basic Medical Biochemistry: A Clinical Approach
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5TH EDITION · Wolters Kluwer