How many ATP equivalents are generated from one acetyl group oxidized in the TCA cycle and oxidative phosphorylation?

Key points

• The TCA cycle produces 3 NADH, 1 FAD(2H), and 1 GTP from one acetyl group.
• Each NADH can generate about 2.5 ATP, and each FAD(2H) about 1.5 ATP during oxidative phosphorylation.
• The total ATP yield from one acetyl group is about 10 high-energy phosphate bonds.