ProcessIntermediate
How should acetylcysteine be administered for acetaminophen toxicity according to the chapter?
Acetylcysteine should be administered orally at a dose of 140 mg/kg initially, followed by 70 mg/kg every 4 hours for a total of 17 doses. Alternatively, it can be given intravenously as a loading dose of 150 mg/kg over 60 minutes, followed by 50 mg/kg over 4 hours, and then 100 mg/kg over 16 hours.
Key points
- Administer acetylcysteine within 8 hours for best results.
- Oral dosing: 140 mg/kg initially, then 70 mg/kg every 4 hours for 17 doses.
- IV dosing: 150 mg/kg loading dose over 60 minutes, then 50 mg/kg over 4 hours, and 100 mg/kg over 16 hours.
- Dilute oral solution with diet soda or water if needed.
- Monitor for effectiveness and side effects during treatment.
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Mosbys 2021 Nursing Drug Reference by Linda Skidmore-Roth
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THIRTY-FOURTH EDITION · Elsevier Inc.